Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease
Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh, Saskia-Larissa Jauch-Speer, Darius P. Schaub, Jonas Engeßer, Malte Hellmig, Vincent Piegsa, Arthur L. Hube, Varshi Sivayoganathan, Alina Borchers, Anett Peters, Anna Kaffke, Stephanie Zielinski, , Christian F. Krebs
This study uses spatial transcriptomics to show that immune and renal cell interactions drive glomerular crescent formation in RPGN through PDGF and TGF-β signaling to PECs.
Nature Immunology · Sep 30, 2025Peer-reviewedImmunology