Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System
Mohit Aspal, Natalie Pushlar, Melina Melameka, Rachael N. McVicar, Emily Smith, Temiloluwa Ogunyamoju, Matangi Kumar, Jamey D. Marth, Jerold J. M. Chun, Evan Y. Snyder, Sandra Lawrynowicz Leibel
This paper develops a human lung organoid model to study senescence, showing increased β-gal activity, SASP cytokines, and fibrosis-like features.
bioRxiv · Feb 24, 2025 · PreprintCell Biology