Emily Smith

Tumor-specific Kinase Motif Enrichment Analysis Identifies Personalized Therapeutic Cancer Targets

The paper uses phosphoproteomic data and KMEA to identify tumor-specific kinase activity in GEP-NETs, revealing potential therapeutic targets.

Sociality changes Gene Essentiality

The paper shows social interactions in phages distort gene essentiality by masking true fitness costs through complementation, and proposes an MOI-based strategy to classify sociality.

Human rhinovirus 16 infection of Hela-Ohio and HEp-2 cells modifies micro RNA expression across the viral life-cycle

This study identifies miRNAs differentially expressed during RV16 infection and links them to host genes involved in antiviral responses and viral progression.

Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System

This paper develops a human lung organoid model to study senescence, showing increased β-gal activity, SASP cytokines, and fibrosis-like features.

Identification of a novel therapeutic agent for Inflammatory Bowel Disease guided by systems medicine

This study identifies clarithromycin as a potential therapeutic for inflammatory bowel disease through in-silico drug repositioning and experimental validation of its effects on NF-κB signaling.