Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Cheemala Ashok, Amy L. Kimble, Jordan D. Tyburski, Nathan K. Leclair, Aamir R. Zuberi, Melissa Murphy, Evan R. Jellison, Bo Reese, Xiangyou Hu, Cathleen M. Lutz, Riqiang Yan, Patrick A. Murphy
This study shows that loss of TDP-43 in brain endothelial cells causes blood-brain barrier defects in mouse models of ALS and FTD.
bioRxiv · Dec 13, 2023 · PreprintNeuroscience