Author

Nathan K. Leclair

The Jackson Laboratory for Genomic MedicineORCID 0000-0002-0401-2549Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Mattia BrugioloiD· 2 shared Olga AnczukówiD· 2 shared Ryan P. EnglanderiD· 2 shared Aamir R. ZuberiiD· 1 shared Amy L. KimbleiD· 1 shared Andrew SalneriD· 1 shared Bo ReeseiD· 1 shared Caleb S. HeffneriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Mattia BrugioloORCID

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Author profile →

3 papers

Recent·Most cited

Splicing of ultraconserved poison exons controls mitotic fidelity and stem cell viability

Nathan K. Leclair, Mattia Brugiolo, Isha A. Walawalkar, Marina Yurieva, Hyeon Gu Kang, Ryan P. Englander, Mallory Ryan, Caleb S. Heffner, Justin A. McDonough, William C. Skarnes, Stephen A. Murray, Olga Anczuków

This study shows that ultraconserved poison exons regulate mitotic splicing fidelity and stem cell viability by controlling SR protein levels and splicing networks.

bioRxiv · May 21, 2026 · PreprintMolecular Biology

Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer

Ryan P. Englander, Mattia Brugiolo, Te-Chia Wu, Mitchell S. Kostich, Nathan K. Leclair, SungHee Park, Jacques Banchereau, Peter Yu, Andrew Salner, Romain Banchereau, Karolina Palucka, Olga Anczuków

The paper identifies intron retention in STAT2 as a regulator of immune signaling and a predictor of immunotherapy response in lung cancer.

bioRxiv · Aug 19, 2025 · PreprintImmunology

Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Cheemala Ashok, Amy L. Kimble, Jordan D. Tyburski, Nathan K. Leclair, Aamir R. Zuberi, Melissa Murphy, Evan R. Jellison, Bo Reese, Xiangyou Hu, Cathleen M. Lutz, Riqiang Yan, Patrick A. Murphy

This study shows that loss of TDP-43 in brain endothelial cells causes blood-brain barrier defects in mouse models of ALS and FTD.

bioRxiv · Dec 13, 2023 · PreprintNeuroscience