Structure-Function Analysis of an Infantile Rhabdomyosarcoma Fusion-Oncogene Reveals Domain Requirements for Tumorigenesis
Chinmay S Sankhe, Delia Calderon, Cenny Taslim, Melissa Sammons, Lindsay Ryan, Katherine M Silvius, Amy C Gross, Olivier Delattre, Joanna Cyrta, Ryan D Roberts, Genevieve C Kendall
This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.
bioRxiv · Nov 3, 2026 · PreprintCancer Biology