Katherine M. Silvius

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

This study investigates HES3's role in development and fusion-positive rhabdomyosarcoma using zebrafish models and finds HES3 regulates neural programs and interacts with PAX3::FOXO1 to influence tumor biology.

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

This study generates and characterizes a zebrafish her3/HES3 knockout to examine its role in neural development and cancer-related pathways.