Ryan David Roberts

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

This study identifies FGFR-ERK signaling as a driver of adaptive resistance in osteosarcoma lung metastases and shows that combinatorial RTK inhibition enhances MCL1 inhibitor efficacy.

This study integrates single-cell and spatial transcriptomic data across species to identify conserved and distinct tumor ecosystems in osteosarcoma, revealing canine models as more faithful and highlighting ECM signaling in metastatic lesions.

SCANBIT identifies tumor cell populations in scRNA-seq data by using pseudobulked SNV calls, showing that mutational burden affects identification accuracy.

This study shows NR0B1 alters the 9-cis-retinoic acid response in Ewing Sarcoma cells by modulating nuclear receptor activity, suggesting NR0B1 inhibition could enhance retinoid therapy.

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.