Genevieve C. Kendall

Structure-Function Analysis of an Infantile Rhabdomyosarcoma Fusion-Oncogene Reveals Domain Requirements for Tumorigenesis

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

HES3-dependent regulatory functions in development and fusion-positive rhabdomyosarcoma

This study investigates HES3's role in development and fusion-positive rhabdomyosarcoma using zebrafish models and finds HES3 regulates neural programs and interacts with PAX3::FOXO1 to influence tumor biology.

Comparative modes of chromatin engagement by PAX::FOXO1 fusions in rhabdomyosarcoma

This paper compares the chromatin engagement mechanisms of PAX3::FOXO1 and PAX7::FOXO1 fusions in rhabdomyosarcoma using modified MNase ChIP and identifies distinct nucleosome targeting patterns.

RNA-SeqEZPZ: A Point-and-Click Pipeline for Comprehensive Transcriptomics Analysis with Interactive Visualizations

RNA-SeqEZPZ is a user-friendly pipeline for RNA-Seq analysis with interactive visualizations, offering both point-and-click and command-line interfaces for reproducible and customizable transcriptomics workflows.

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing

The paper introduces a low-cost, flexible method for quantitative chromatin sequencing and enables cross-species epigenomic comparisons.

Engineering an fgfr4 knockout zebrafish to study its role in development and disease

This study generates and characterizes fgfr4 knockout zebrafish to investigate FGFR4's role in development and disease.

New Dual Inducible Cellular Model to Investigate Temporal Control of Oncogenic Cooperating Genes

The paper develops a dual-inducible cellular model to study the temporal control of oncogenic cooperating genes in rhabdomyosarcoma.

Zebrafish her3 knockout impacts developmental and cancer-related gene signatures

This study generates and characterizes a zebrafish her3/HES3 knockout to examine its role in neural development and cancer-related pathways.