PRAMEL7/CUL2 axis regulates NuRD stability to establish ground-state pluripotency in embryonic stem cells
Meneka Rupasinghe, Cristiana Bersaglieri, Deena M Leslie Pedrioli, Patrick G. A. Pedrioli, Martina Panatta, Michael O. Hottiger, Paolo Cinelli, Raffaella Santoro
This study shows PRAMEL7 interacts with CUL2 to destabilize NuRD complex, promoting ground-state pluripotency in ESCs by reducing repressive chromatin regulation.
bioRxiv · Oct 10, 2022Developmental Biology