Michael O. Hottiger

PARP16 protects against pathological cardiac remodelling by ADP-ribosylation-dependent inhibition of NFAT transcription factor

This study shows PARP16 reduces cardiac remodelling by inhibiting NFAT transcription through ADP-ribosylation, with implications for heart failure treatment.

PARP6-dependent vimentin ADP-ribosylation prevents myofibroblast activation in cardiac fibrosis

PARP14-dependent ADP-ribosylation of cytoplasmic SQSTM1/p62 foci supports innate immune signaling

The paper identifies PARP14-dependent ADP-ribosylation of p62 foci as a mechanism supporting innate immune signaling through interferon pathways.

PRAMEL7/CUL2 axis regulates NuRD stability to establish ground-state pluripotency in embryonic stem cells

This study shows PRAMEL7 interacts with CUL2 to destabilize NuRD complex, promoting ground-state pluripotency in ESCs by reducing repressive chromatin regulation.

Development of a mass-spectrometry based method for the identification of the in vivo whole blood and plasma ADP-ribosylomes

The paper develops a mass-spectrometry method to identify ADP-ribosylomes in whole blood and plasma, finding 60 ADP-ribosylated proteins in LPS-treated pigs.