Revealing the antibiotic resistome in the global hadal trenches by large-scale cultivation and metagenomics
Xiang Cheng, Xiaojie Qiu, Naijia Shen, Hui Zhou, Mengjie Zhang, Zhe‐Xue Quan, Guoqing Zhang, Jiasong Fang, Xuan Li, Guoping Zhao, Pei Hao, Ping Chen
This study investigates antibiotic resistance genes and bacteria in hadal trench sediments using cultivation and metagenomics, finding a pristine reservoir with distinct ARG dynamics and phylogenetic clusters.
bioRxiv · Dec 11, 2025 · PreprintMicrobiology