Xuan Li

Revealing the antibiotic resistome in the global hadal trenches by large-scale cultivation and metagenomics

This study investigates antibiotic resistance genes and bacteria in hadal trench sediments using cultivation and metagenomics, finding a pristine reservoir with distinct ARG dynamics and phylogenetic clusters.

DENA: training an authentic neural network model using Nanopore sequencing data of Arabidopsis transcripts for detection and quantification of N6-methyladenosine on RNA

The paper introduces DENA, a neural network model trained on Nanopore sequencing data to detect and quantify N6-methyladenosine (m6A) in RNA, showing high accuracy in Arabidopsis and consistency with human data.

Vorinostat corrects cognitive and non-cognitive symptoms in a mouse model of fragile X syndrome

This study shows that vorinostat improves cognitive and non-cognitive symptoms in a mouse model of fragile X syndrome without affecting abnormal protein synthesis.

Expanding the Coverage of the Metabolic Landscape in Cultivated Rice with Integrated Computational Approaches

The paper expands metabolite annotation coverage in rice using integrated computational approaches and reveals differential flavonoid accumulation between indica and japonica cultivars.

Computational analysis of transcriptome signature repurposes low dose trifluoperazine for the treatment of fragile X syndrome in mouse model

The paper identifies trifluoperazine as a potential treatment for FXS using transcriptome analysis and experimental validation.

Implementation of CRISPR-Cas13a system in fission yeast and its repurposing for precise RNA editing

The paper implements and repurposes the CRISPR-Cas13a system in fission yeast for precise RNA editing, demonstrating reduced off-target effects and programmable nucleotide editing.