CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signaling
Theodoros Ioannis Papadimitriou, A. Essen, Merel Willemse, Daphne N. Dorst, E.L. Vitters, Birgitte Walgreen, Hans J. P. M. Koenen, Peter M van der Kraan, Marije I. Koenders, Rogier M. Thurlings, A. van Caam
This study shows CD8+ T cells drive myofibroblast activation and contraction through JAK/STAT3 and TGFβ signaling, not cytotoxicity, and suggests combined inhibition of these pathways could treat fibrosis.
iScience · Oct 30, 2025Peer-reviewedImmunology