Author

Daphne N. Dorst

Radboud University Medical CenterORCID 0000-0002-9292-0693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. van CaamiD· 2 shared Birgitte Walgreen· 2 shared E.L. VittersiD· 2 shared A. Essen· 1 shared Djúlio César Zanin-SilvaiD· 1 shared Hans J. P. M. KoeneniD· 1 shared M. H. J. van den Bosch· 1 shared Marije I. KoendersiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

A. van CaamORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MONOCYTES STRONGLY INDUCE (MYO)FIBROBLAST CONTRACTION IN A NEW 3D SKIN MODEL TO UNDERSTAND THE INFLAMMATION-FIBROSIS AXIS IN SYSTEMIC SCLEROSIS

Djúlio César Zanin-Silva, Nienke J T van Kooten, Theogiannis I. Papadimitriou, Daphne N. Dorst, Birgitte Walgreen, E.L. Vitters, M. H. J. van den Bosch, Marije Koenders, A. van Caam

This study uses a 3D skin model to show that monocytes and macrophages induce myofibroblast contraction via JAK/STAT3 and TGF-β signaling in systemic sclerosis.

bioRxiv · Feb 14, 2026 · PreprintImmunology

CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signaling

Theodoros Ioannis Papadimitriou, A. Essen, Merel Willemse, Daphne N. Dorst, E.L. Vitters, Birgitte Walgreen, Hans J. P. M. Koenen, Peter M van der Kraan, Marije I. Koenders, Rogier M. Thurlings, A. van Caam

This study shows CD8+ T cells drive myofibroblast activation and contraction through JAK/STAT3 and TGFβ signaling, not cytotoxicity, and suggests combined inhibition of these pathways could treat fibrosis.

iScience · Oct 30, 2025Peer-reviewedImmunology