GRK-dependent ACKR3 endocytosis and chemokine scavenging is independent of receptor phosphorylation and beta-arrestin
Boubacar Sidiki Traore, Sabrina Casella, Pierre Couvineau, Meriem Semache, Diego Morone, Gianluca D’Agostino, Sylvia Thelen, Billy Breton, Pedro Henrique Scarpelli Pereira, Mariagrazia Uguccioni, Daniel F. Legler, Marcus Thelen, Michel Bouvier
This study shows that GRKs are essential for ACKR3 endocytosis and chemokine scavenging, while β-arrestins and receptor phosphorylation are not required.
bioRxiv · May 13, 2026 · PreprintCell Biology