Author

Pierre Couvineau

Centre National de la Recherche ScientifiqueORCID 0000-0002-4905-7740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Aurélien FouilleniD· 1 shared Bernard MouillaciD· 1 shared Billy BretoniD· 1 shared Boubacar Sidiki TraoreiD· 1 shared Charline MaryiD· 1 shared Christiane MendreiD· 1 shared Daniel F. LegleriD· 1 shared Diego MoroneiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aurélien FouillenORCID

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2 papers

Recent·Most cited

GRK-dependent ACKR3 endocytosis and chemokine scavenging is independent of receptor phosphorylation and beta-arrestin

Boubacar Sidiki Traore, Sabrina Casella, Pierre Couvineau, Meriem Semache, Diego Morone, Gianluca D’Agostino, Sylvia Thelen, Billy Breton, Pedro Henrique Scarpelli Pereira, Mariagrazia Uguccioni, Daniel F. Legler, Marcus Thelen, Michel Bouvier

This study shows that GRKs are essential for ACKR3 endocytosis and chemokine scavenging, while β-arrestins and receptor phosphorylation are not required.

bioRxiv · May 13, 2026 · PreprintCell Biology

Inactive structures of the vasopressin V2 receptor reveal distinct antagonist binding modes for Tolvaptan and Mambaquaretin toxin

Aurélien Fouillen, Julien Bous, Pierre Couvineau, Hélène Orcel, Charline Mary, Lucie Lafleur, Timothé Pierre, Christiane Mendre, Nicolas Gilles, Gunnar Schulte, Sébastien Granier, Bernard Mouillac

The paper solves cryo-EM structures of the V2R bound to Tolvaptan and Mambaquaretin toxin, revealing distinct antagonist binding modes and inactive conformations.

Nature Communications · Apr 24, 2025Peer-reviewedPharmacology & Toxicology