Daniel F. Legler

This study shows LRH-1 is essential for early T cell development and functional CD4 T cell responses in mice.

This study shows that GRKs are essential for ACKR3 endocytosis and chemokine scavenging, while β-arrestins and receptor phosphorylation are not required.

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

This study shows that plasmacytoid dendritic cells (pDCs) are critical for both humoral and CD8⁺ T cell memory responses after Pfizer-BioNTech mRNA vaccination.

This study identifies GPR182/ACKR5 as a scavenger receptor for CXCL17, GPR15L, and endogenous peptides, revealing distinct binding modes and expanding its ligand repertoire beyond classical chemokines.