Quinolinic acid links kidney injury to brain toxicity
Afaf Saliba, Subrata Debnath, Ian M. Tamayo, Jana Tůmová, Meyer Maddox, Pragya Singh, Caitlyn Fastenau, Soumya Maity, Hak Joo Lee, Guanshi Zhang, Leila Hejazi, Jason C. O’Connor, Bernard Fongang, Sarah C. Hopp, Kevin F. Bieniek, , Kumar Sharma
This study identifies quinolinic acid as a key metabolite linking kidney injury to brain toxicity through the kynurenine pathway in mice and humans.
bioRxiv · May 7, 2024 · PreprintMolecular Biology