Jason C. O’Connor

This study identifies quinolinic acid as a mediator of kidney injury and fibrosis, suggesting it as a potential therapeutic target for preventing AKI-to-CKD progression.

This study identifies quinolinic acid as a key metabolite linking kidney injury to brain toxicity through the kynurenine pathway in mice and humans.

This study identifies the kynurenine metabolic pathway as a key factor in sustaining neuropathic pain through interactions between meningeal dendritic cells and astrocytes.