Structure-Guided Discovery of High-Affinity Methotrexate Aptamers for Electrochemical Drug Monitoring
Micaela Sequeira, Thiago Coimbra Pimenta, Rafael Vieira, Alexander S. Beliaev, Kirill A. Alexandrov, Sérgio Filipe Sousa, Saimon Moraes Silva, Elena Eremeeva
This paper develops two high-affinity MTX-binding DNA aptamers using structure-guided methods and validates their use in electrochemical drug monitoring.
bioRxiv · Oct 7, 2026 · PreprintBioengineering