Author

Alexander S. Beliaev

Pacific Northwest National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Ali Jahanian· 1 shared Anh Phan· 1 shared Benjamin I. TickmaniD· 1 shared Bingyin PengiD· 1 shared Brianne King· 1 shared Chengqiang WangiD· 1 shared Claudia Estelle VickersiD· 1 shared Craig P. BarryiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSynthetic Biology

Ali Jahanian

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Author profile →

3 papers

Recent·Most cited

Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits

Zeyu Mike Lu, Craig P. Barry, Masahiro Tominaga, Anh Phan, Ali Jahanian, Thomas Collier, Nicholas A. Wendrick, Samuel Evans, Liam McDonnell, Gabriele A. Netzel, Tim McCubbin, Shana Sunny Jacob, Patrick A. da Roza, Xin Xu, Chengqiang Wang, , Bingyin Peng

The paper develops synthetic genetic circuits in yeast to stabilize metabolic stress from terpene production, showing that coupling essential genes to synthetic pathways improves strain stability.

bioRxiv · Oct 9, 2026 · PreprintSynthetic Biology

Structure-Guided Discovery of High-Affinity Methotrexate Aptamers for Electrochemical Drug Monitoring

Micaela Sequeira, Thiago Coimbra Pimenta, Rafael Vieira, Alexander S. Beliaev, Kirill A. Alexandrov, Sérgio Filipe Sousa, Saimon Moraes Silva, Elena Eremeeva

This paper develops two high-affinity MTX-binding DNA aptamers using structure-guided methods and validates their use in electrochemical drug monitoring.

bioRxiv · Oct 7, 2026 · PreprintBioengineering

Carbon-conserving Bioproduction of Malate in an E. coli-based Cell-Free System

Ryan A. L. Cardiff, Shaafique Chowdhury, Widianti Sugianto, Benjamin I. Tickman, Diego Alba Burbano, Pimphan A. Meyer, Margaret Cook, Brianne King, David Garenne, Alexander S. Beliaev, Vincent Noireaux, Pamela Peralta‐Yahya, James M. Carothers

This paper engineers a carbon-conserving cell-free system in E. coli to produce malate from formate and bicarbonate, achieving a 15-fold increase in titer and reducing background reactions by 6-fold.

Metabolic Engineering · Apr 8, 2025Peer-reviewedSynthetic Biology