Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Taslima Gani Khan, Juliana Bragazzi Cunha, Chinmay Raut, Michael Burroughs, Hitarthi Vyas, Kyle Leix, Sascha N. Goonewardena, Alan V. Smrcka, Elizabeth K. Speliotes, Brian T. Emmer
This study uses genome-scale CRISPR screening to identify LDLR and MYLIP as key regulators of Lp(a) uptake in HuH7 cells, with validation in a UK Biobank cohort.
Atherosclerosis · Mar 22, 2025Peer-reviewedGenetics