Author

Sascha N. Goonewardena

University of MichiganORCID 0000-0002-3772-8818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Afnan AlzamrooniiD· 1 shared Ahmed Abdel‐LatifiD· 1 shared Alan V. SmrckaiD· 1 shared Alexander AhniD· 1 shared Anand Prakash SinghiD· 1 shared Andrew T. LudlowiD· 1 shared Anis IsmailiD· 1 shared Brian M. SchmidtiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

Afnan AlzamrooniORCID

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Author profile →

3 papers

Recent·Most cited

Wound healing and angiogenic profiling of dermal endothelial cells isolated from people with type 2 diabetes.

James Shadiow, Corey E. Mazo, Pallavi Varshney, Jeongjin Kim, Alexander Ahn, Sophie H. Chong, Cory A. Lutz, Crystal Holmes, Michael E. Munson, Brian M. Schmidt, Sascha N. Goonewardena, Richard D. Minshall, Thomas P. J. Solomon, Andrew T. Ludlow, Jacob M. Haus

This study examines dermal endothelial cells from people with type 2 diabetes, finding they have altered migratory, angiogenic, and gene expression profiles compared to healthy cells.

The FASEB Journal · Jun 12, 2026Peer-reviewedPhysiology

Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction

Anand Prakash Singh, Parisa Shabani, Anis Ismail, Rajesh Kumar Chaudhary, Afnan Alzamrooni, Tahra Kaur Luther, Matthew Nho, Rachel Lopez‐Schenk, Chetna Soni, Sascha N. Goonewardena, Salim S. Hayek, Ahmed Abdel‐Latif

This paper shows that elevated suPAR worsens HFpEF by priming macrophages and amplifying inflammatory responses, identifying a therapeutic target for anti-suPAR antibodies.

bioRxiv · Jun 9, 2026 · PreprintImmunology

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening

Taslima Gani Khan, Juliana Bragazzi Cunha, Chinmay Raut, Michael Burroughs, Hitarthi Vyas, Kyle Leix, Sascha N. Goonewardena, Alan V. Smrcka, Elizabeth K. Speliotes, Brian T. Emmer

This study uses genome-scale CRISPR screening to identify LDLR and MYLIP as key regulators of Lp(a) uptake in HuH7 cells, with validation in a UK Biobank cohort.

Atherosclerosis · Mar 22, 2025Peer-reviewedGenetics