Brian T. Emmer

This study uses multiple functional genomic approaches to identify and characterize cis-regulatory elements (CREs) influencing LDLR expression, revealing overlapping yet distinct CREs across methods.

This study uses genome-scale CRISPR screening to identify LDLR and MYLIP as key regulators of Lp(a) uptake in HuH7 cells, with validation in a UK Biobank cohort.

The paper uses CRISPR screening to identify a functional enhancer in the first intron of LDLR that influences LDL uptake and is associated with LDL cholesterol levels.

The paper shows that SAR1A and SAR1B paralogs have overlapping functions in mice, with SAR1A compensating for SAR1B deficiency.

This study identifies PROX1 and CHD7 as regulators of LDL uptake, with PROX1 directly enhancing LDLR expression and CHD7 acting through an LDLR-independent mechanism.

This study uses CRISPR screening to identify 35 genes that modify ACE2 surface abundance in HuH7 cells, revealing regulators of ACE2 expression and their impact on SARS-CoV-2 susceptibility.

The paper uses genome-scale CRISPR screening to identify genetic modifiers of LDL uptake in hepatocytes, finding several new genes involved in this process.