Kyle Leix

This study uses multiple functional genomic approaches to identify and characterize cis-regulatory elements (CREs) influencing LDLR expression, revealing overlapping yet distinct CREs across methods.

This study uses genome-scale CRISPR screening to identify LDLR and MYLIP as key regulators of Lp(a) uptake in HuH7 cells, with validation in a UK Biobank cohort.

The paper uses CRISPR screening to identify a functional enhancer in the first intron of LDLR that influences LDL uptake and is associated with LDL cholesterol levels.