Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART
Vincent H. Wu, Jayme M.L. Nordin, María Betina Pampena, Suzanna Rachimi, William L. Burgess, Michael Clark, Jake A. Robinson, Perla M. Del Río Estrada, Mariane Høgsbjerg Schleimann, Fernanda Torres-Ruiz, Mauricio González-Navarro, Gonzalo Salgado Salgado, Yara Andrea Luna-Villalobos, Gustavo Reyes‐Terán, Katharine J. Bar, , Michael R. Betts
This study identifies a noncanonical PRDM1+ Tfh subset selectively depleted in HIV viremia but recoverable under ART, highlighting its susceptibility to infection and implications for HIV reservoirs.
bioRxiv · Dec 15, 2025 · PreprintImmunology