Michael R. Betts

In vivo reprogramming of cytotoxic effector CD8+ T cells via fractalkine-conjugated mRNA-LNP

This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

This study uses spatial transcriptomics to identify inflammation signatures in pancreas and lymph node tissues of T1D patients, highlighting LTB and other genes involved in disease pathogenesis.

Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART

This study identifies a noncanonical PRDM1+ Tfh subset selectively depleted in HIV viremia but recoverable under ART, highlighting its susceptibility to infection and implications for HIV reservoirs.

Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease

This study identifies disrupted lymphocyte chemotaxis in idiopathic multicentric Castleman disease, linking dysregulated chemokine production to germinal center dysfunction and lymphadenopathy.

Therapeutic CD8+T cell tissue retention and immunomodulation during ART interruption fails to prevent SIV rebound

This study shows that retaining CD8+ T cells in lymphoid tissues during ART interruption does not prevent SIV rebound, even with immunomodulators.

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

The paper analyzes immune cell changes in human pancreas-draining lymphatic tissues before and after T1D onset, identifying proinflammatory patterns and genetic risk correlations.

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes