Author

Vincent H. Wu

The Wistar InstituteORCID 0000-0002-8640-6065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 2 Organism:human· 2 Organism:rat· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

María Betina PampenaiD· 4 shared Michael R. BettsiD· 4 shared Jacob T. HamiltoniD· 2 shared Jayme M.L. NordiniD· 2 shared Katharine J. BariD· 2 shared Leticia Kuri-CervantesiD· 2 shared Mirko PaiardiniiD· 2 shared Alberto Sada JappiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

María Betina PampenaORCID

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4 papers

Recent·Most cited

In vivo reprogramming of cytotoxic effector CD8+ T cells via fractalkine-conjugated mRNA-LNP

Angela R. Corrigan, Shin Foong Ngiow, Maura Statzu, Amie Albertus, María Betina Pampena, Jayme M.L. Nordin, Stephen D. Carro, Justin L. Harper, Rachelle L. Stammen, Jennifer Wood, Houping Ni, Justin Su, Marziyeh Hajialyani, Vladimir V. Shuvaev, Víctor Alcalde, , Michael R. Betts

This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.

Science Immunology · May 29, 2026Peer-reviewedImmunology

Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART

Vincent H. Wu, Jayme M.L. Nordin, María Betina Pampena, Suzanna Rachimi, William L. Burgess, Michael Clark, Jake A. Robinson, Perla M. Del Río Estrada, Mariane Høgsbjerg Schleimann, Fernanda Torres-Ruiz, Mauricio González-Navarro, Gonzalo Salgado Salgado, Yara Andrea Luna-Villalobos, Gustavo Reyes‐Terán, Katharine J. Bar, , Michael R. Betts

This study identifies a noncanonical PRDM1+ Tfh subset selectively depleted in HIV viremia but recoverable under ART, highlighting its susceptibility to infection and implications for HIV reservoirs.

bioRxiv · Dec 15, 2025 · PreprintImmunology

Therapeutic CD8+T cell tissue retention and immunomodulation during ART interruption fails to prevent SIV rebound

María Betina Pampena, Sadia Samer, Elise G. Viox, Kevin Nguyen, Claire Deléage, Leticia Kuri-Cervantes, James Regan, Vincent H. Wu, Steffen S. Docken, Jeffrey T. Safrit, Katharine J. Bar, Brandon F. Keele, Miles P. Davenport, Mirko Paiardini, Michael R. Betts

This study shows that retaining CD8+ T cells in lymphoid tissues during ART interruption does not prevent SIV rebound, even with immunomodulators.

Proceedings of the National Academy of Sciences · Aug 14, 2025Peer-reviewedImmunology

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

Gregory J. Golden, Vincent H. Wu, Jacob T. Hamilton, Kevin R. Amses, Melanie R. Shapiro, Alberto Sada Japp, Chengyang Liu, María Betina Pampena, Leticia Kuri-Cervantes, James J. Knox, Jay S. Gardner, Mark A. Atkinson, Todd M. Brusko, Eline T. Luning Prak, Klaus H. Kaestner, , Michael R. Betts

The paper analyzes immune cell changes in human pancreas-draining lymphatic tissues before and after T1D onset, identifying proinflammatory patterns and genetic risk correlations.

Nature Communications · May 18, 2025Peer-reviewedImmunology