Author

Jacob D. Estes

Division of Pathobiology and Immunology, ONPRC, Department of Molecular Microbiology & Immunology, Oregon Health & Science University, United States of America;ORCID 0000-0002-9652-6394Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:rat· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Kathleen Busman‐SahayiD· 2 shared Aaron M. Barber-Axthelm· 1 shared Afam A. OkoyeiD· 1 shared Alec J. HirschiD· 1 shared Anca DorhoiiD· 1 shared Andrea M. WeileriD· 1 shared Andrea N. SelsethiD· 1 shared Ayanda ShabanguiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Kathleen Busman‐SahayORCID

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Author profile →

4 papers

Recent·Most cited

Spatial transcriptomics of pediatric tuberculosis lymph nodes reveals a conserved hypoxia_SPP1 niche

S Odunola Adebiyi, Pierre Goussard, Daniel R. De Wet, Jacques T. Janson, Tracey Jooste, Ayanda Shabangu, Anca Dorhoi, Stephen Bondoc, Michael Nekorchuk, Michael C. Chao, Sarah M. Fortune, Kathleen Busman-Sahay, Jacob D. Estes, Elya A. Shamskhou, Kevin B Urdahl, , Nelita Du Plessis

This study uses spatial transcriptomics to identify a hypoxia-associated SPP1-enriched microenvironment in pediatric TB granulomas that may contribute to incomplete bacterial clearance.

bioRxiv · Nov 3, 2026 · PreprintImmunology

Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infection

Maanasa Kaza, Benjamin D. Varco-Merth, GW McElfresh, Sebastián Benjamín, Gregory J. Boggy, Morgan Chaunzwa, Shana Feltham, Sohita Ojha, Karina Belica, Andrea N. Selseth, Michael D. Nekorchuk, Kathleen Busman‐Sahay, Brandon F. Keele, Dan H. Barouch, Jeffrey D. Lifson, , Benjamin N. Bimber

The paper identifies two distinct phases of immune system changes in ART-suppressed HIV infection using single-cell transcriptomics and proteomics in rhesus macaques.

Cell Reports · Sep 30, 2026Peer-reviewedImmunology

Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART

Vincent H. Wu, Jayme M.L. Nordin, María Betina Pampena, Suzanna Rachimi, William L. Burgess, Michael Clark, Jake A. Robinson, Perla M. Del Río Estrada, Mariane Høgsbjerg Schleimann, Fernanda Torres-Ruiz, Mauricio González-Navarro, Gonzalo Salgado Salgado, Yara Andrea Luna-Villalobos, Gustavo Reyes‐Terán, Katharine J. Bar, , Michael R. Betts

This study identifies a noncanonical PRDM1+ Tfh subset selectively depleted in HIV viremia but recoverable under ART, highlighting its susceptibility to infection and implications for HIV reservoirs.

bioRxiv · Dec 15, 2025 · PreprintImmunology

A Zika Virus-Like Particle Vaccine Mitigates Early Pregnancy Loss In Rhesus Macaques

Hannah K. Jaeger, Jessica R. Smith, Caralyn S. Labriola, Lydia J. Pung, Olivia L. Hagen, Michael C. Denton, Rahul J. D'Mello, Christopher J. Parkins, Whitney C. Weber, Samuel Medica, Craig N. Kreklywich, Victor R. DeFilippis, Stephen Bondoc, Kathleen Busman‐Sahay, Jenna N. Castro, , Alec J. Hirsch

This study evaluates a Zika virus-like particle (VLP) vaccine in rhesus macaques, showing it reduces early pregnancy loss caused by a highly pathogenic ZIKV strain.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology