APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell Carcinoma
Daniel L. Faden, Krystle A. Lang Kuhs, Maoxuan Lin, Adam Langenbucher, Maísa Pinheiro, Meredith Yeager, Michael Cullen, Joseph F. Boland, Mia K. Steinberg, Sara E. Bass, James S. Lewis, Michael S. Lawrence, Robert Louis Ferris, Lisa J. Mirabello
This study shows that APOBEC mutagenesis occurs in both tumor and viral genomes in HPV+ OPSCC, suggesting a direct link between viral restriction and host mutations.
Viruses · Aug 23, 2021Peer-reviewedGenomics