Joseph F. Boland

This paper investigates the mechanisms of ADC-immunotherapy combinations, finding that ADC-induced autophagy upregulates TNFR and M6PR, driving antitumor effects through TNF and granzyme B pathways.

The paper develops a method for single-nucleus RNA-seq of archived PAXgene whole blood samples, achieving high nuclei yields and unbiased cell-type representation through optimized isolation and globin depletion.

This study shows that APOBEC mutagenesis occurs in both tumor and viral genomes in HPV+ OPSCC, suggesting a direct link between viral restriction and host mutations.