Author

James S. Lewis

Mayo ClinicORCID 0000-0001-9002-1283Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Adam LangenbucheriD· 1 shared Amanda Y. XiaiD· 1 shared Andreas WielandiD· 1 shared Colby J. HofferekiD· 1 shared Daniel L. FadeniD· 1 shared David J. HernandeziD· 1 shared Emerald Kan· 1 shared Joseph F. BolandiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Adam LangenbucherORCID

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2 papers

Recent·Most cited

ImmunologyScience ImmunologyPeer-reviewedApr 10, 2026

Single-cell, Spatially-Resolved TCR Profiling Links T Cell Phenotype and Clonality in Human Tumors

Kelli A. McCord, Emerald Kan, Sean Hyslop…·William Henry Hudson

The paper develops a multimodal profiling framework to analyze T cell phenotype and clonality in HNSCC tumors, revealing spatial and antigen-specific differences in T cell function.

8 citationstop 1%

humanscRNA-seq

𝕏 PostBluesky

GenomicsVirusesPeer-reviewedAug 23, 2021

APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell Carcinoma

Daniel L. Faden, Krystle A. Lang Kuhs, Maoxuan Lin…·Lisa J. Mirabello

This study shows that APOBEC mutagenesis occurs in both tumor and viral genomes in HPV+ OPSCC, suggesting a direct link between viral restriction and host mutations.

35 citationstop 4%

humanwhole-exome sequencing

𝕏 PostBluesky