Author

Michael D. Holsey

New York State Psychiatric Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alekhya M. GovindarajuiD· 1 shared Alexey BondariD· 1 shared Chase M. WebbiD· 1 shared George V. DukasiD· 1 shared Jonathan A. JavitchiD· 1 shared Meritxell CanalsiD· 1 shared Nevin A. LambertiD· 1 shared Peter Geggier· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alekhya M. GovindarajuORCID

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1 paper

Recent·Most cited

Local GPCR density tips the balance of μ-opioid receptor trafficking

Michael D. Holsey, Alexey Bondar, Peter Geggier, George V. Dukas, Chase M. Webb, Alekhya M. Govindaraju, Signe Mathiasen, Meritxell Canals, Nevin A. Lambert, Wesley B. Asher, Jonathan A. Javitch

This study shows that increasing μ-opioid receptor density promotes trafficking via GRK2/3 and β-arrestin interactions, while class B GPCRs block trafficking by sequestering β-arrestin.

bioRxiv · Feb 28, 2026 · PreprintBiophysics