Local GPCR density tips the balance of μ-opioid receptor trafficking
Michael D. Holsey, Alexey Bondar, Peter Geggier, George V. Dukas, Chase M. Webb, Alekhya M. Govindaraju, Signe Mathiasen, Meritxell Canals, Nevin A. Lambert, Wesley B. Asher, Jonathan A. Javitch
This study shows that increasing μ-opioid receptor density promotes trafficking via GRK2/3 and β-arrestin interactions, while class B GPCRs block trafficking by sequestering β-arrestin.
bioRxiv · Feb 28, 2026 · PreprintBiophysics