Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Isabella Jaen Maisonet, Mona Sharafi, Emilie J. Korchak, Andres F. Salazar‐Chaparro, Ariana S. Bratt, Tvesha Parikh, Anthony C. Varca, Binita Shah, Michael G. Darnowski, Mia Chung, Wei Pin Teh, Jianwei Che, Irina Bezsonova, Sara J. Buhrlage
This study identifies and characterizes MS-8, a small-molecule activator of USP7, showing it activates mutant USP7 in a cellular context and impacts downstream proteins.
Proceedings of the National Academy of Sciences · Oct 14, 2025Peer-reviewedBiochemistry