Author

Emilie J. Korchak

UConn HealthORCID 0000-0002-6091-8636Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Irina BezsonovaiD· 5 shared Andres F. Salazar‐Chaparro· 2 shared Isabella Jaen MaisonetiD· 2 shared Mona Sharafi· 2 shared Nicholas William AshtoniD· 2 shared Sara J. BuhrlageiD· 2 shared Alan D. D’AndreaiD· 1 shared Alison O’NeiliD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersBiochemistry

Irina BezsonovaORCID

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Author profile →

5 papers

Recent·Most cited

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality

Nicholas William Ashton, Ramya Ravindranathan, Emilie J. Korchak, Ozge Somuncu, Gabriella A. Zambrano, Sirisha Mukkavalli, Shuhei Asada, Dmitry M. Korzhnev, Irina Bezsonova, Alan D. D’Andrea

This paper identifies a PIP motif in RAD18 essential for PCNA ubiquitination and shows USP1 inhibition leads to synthetic lethality in BRCA1-deficient cells.

bioRxiv · May 10, 2026 · PreprintBiochemistry

Mechanisms of USP7/MAGEL2 Complex Assembly and Its Mutational Disruption in Neurodevelopmental Diseases

Emilie J. Korchak, Gabriela Soriano, Irina Semenova, Bing Hao, Denis Štepihar, Tara Bayat, Klementina Fon Tacer, Irina Bezsonova

This study investigates the assembly mechanism of the USP7/MAGEL2 complex and identifies mutations that disrupt its formation, linking it to neurodevelopmental diseases.

bioRxiv · Apr 28, 2026 · PreprintBiochemistry

DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation

Natália Cestari Moreno, Emilie J. Korchak, Marcela Teatin Latância, Dana A. D’Orlando, Temidayo Adegbenro, Ryan P. Barnes, Irina Bezsonova, Roger Woodgate, Nicholas William Ashton

This study shows DNA polymerase η is regulated by both mono-ubiquitination and mono-NEDDylation at the same lysine residues, with NEDDylation disrupting foci formation.

Nucleic Acids Research · Jan 28, 2026Peer-reviewedBiochemistry

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)

Isabella Jaen Maisonet, Mona Sharafi, Emilie J. Korchak, Andres F. Salazar‐Chaparro, Ariana S. Bratt, Tvesha Parikh, Anthony C. Varca, Binita Shah, Michael G. Darnowski, Mia Chung, Wei Pin Teh, Jianwei Che, Irina Bezsonova, Sara J. Buhrlage

This study identifies and characterizes MS-8, a small-molecule activator of USP7, showing it activates mutant USP7 in a cellular context and impacts downstream proteins.

Proceedings of the National Academy of Sciences · Oct 14, 2025Peer-reviewedBiochemistry

Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme's Activity, Stability, and Allosteric Modulation

Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Andres F. Salazar‐Chaparro, Irina V. Semenova, Hamza Khan, Alison O’Neil, Pilar Caro, Christian P. Schaaf, Sara J. Buhrlage, Irina Bezsonova

This study analyzes 11 USP7 variants in Hao-Fountain syndrome, showing they affect enzyme activity, stability, and substrate recognition, with some variants responsive to an allosteric activator.

Proceedings of the National Academy of Sciences · Sep 22, 2025Peer-reviewedBiochemistry