Author

Mona Sharafi

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andres F. Salazar‐Chaparro· 2 shared Emilie J. KorchakiD· 2 shared Irina BezsonovaiD· 2 shared Isabella Jaen MaisonetiD· 2 shared Sara J. BuhrlageiD· 2 shared Alison O’NeiliD· 1 shared Anthony C. VarcaiD· 1 shared Ariana S. BrattiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Andres F. Salazar‐Chaparro

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)

Isabella Jaen Maisonet, Mona Sharafi, Emilie J. Korchak, Andres F. Salazar‐Chaparro, Ariana S. Bratt, Tvesha Parikh, Anthony C. Varca, Binita Shah, Michael G. Darnowski, Mia Chung, Wei Pin Teh, Jianwei Che, Irina Bezsonova, Sara J. Buhrlage

This study identifies and characterizes MS-8, a small-molecule activator of USP7, showing it activates mutant USP7 in a cellular context and impacts downstream proteins.

Proceedings of the National Academy of Sciences · Oct 14, 2025Peer-reviewedBiochemistry

Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme's Activity, Stability, and Allosteric Modulation

Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Andres F. Salazar‐Chaparro, Irina V. Semenova, Hamza Khan, Alison O’Neil, Pilar Caro, Christian P. Schaaf, Sara J. Buhrlage, Irina Bezsonova

This study analyzes 11 USP7 variants in Hao-Fountain syndrome, showing they affect enzyme activity, stability, and substrate recognition, with some variants responsive to an allosteric activator.

Proceedings of the National Academy of Sciences · Sep 22, 2025Peer-reviewedBiochemistry