Intracranial hypertension drives astrocyte-mediated neuroinflammation through Piezo1-dependent EGFR activation
Zongren Zhao, Andrea Hoffmann, Fan Sun, Tamara Merz, Florian Olde Heuvel, Burak Özkan, Franziska Münz, Enrico Calzia, Michael Gröger, Sandra Kress, Peter Radermacher, Francesco Roselli, Thomas Kapapa, Marica Pagliarini
This study identifies a mechanosensitive astrocyte signaling pathway linking intracranial pressure to neuroinflammation via Piezo1-dependent EGFR activation.
bioRxiv · May 2, 2025 · PreprintNeuroscience