Hearts may grow concentrically to balance ATP supply and demand and eccentrically to stabilize titin-based stress
John R. Kotter, Steve Leung, Thomas Kampourakis, Lik-Chuan Lee, Jonathan F. Wenk, Michael J. Moulton, Bertrand C.W. Tanner, Stuart G. Campbell, Christopher M. Yengo, Kerry S. McDonald, Julian E. Stelzer, Kenneth S. Campbell
This paper uses simulations to show that concentric and eccentric cardiac growth are regulated by ATP homeostasis and titin-based stress, respectively, and can model growth patterns from both genetic and clinical causes.
bioRxiv · May 13, 2026 · PreprintBiophysics