Christopher M. Yengo

This study shows that two MYO1E mutations, A92E and G562R, impair Myo1e localization and function, contributing to steroid-resistant nephrotic syndrome.

This study investigates how the E525K mutation in cardiac myosin affects its structure and function by analyzing conformational changes using cryo-EM and MD simulations.

This paper uses simulations to show that concentric and eccentric cardiac growth are regulated by ATP homeostasis and titin-based stress, respectively, and can model growth patterns from both genetic and clinical causes.

The paper uses cryo-EM to determine the structures of myosin bound to two cardiomyopathy drugs, revealing how they modulate myosin conformation to control cardiac contractility.

QuickStainer improves preservation of labile macromolecules by rapidly staining samples with minimal incubation time on the carbon grid.

This paper examines how the E525K mutation in human β-cardiac myosin affects its super-relaxed state and contractility in dilated cardiomyopathy.