The HUSH complex controls brain architecture and protocadherin fidelity
Astrid Hagelkrüys, Marion Horrer, Jasmin Taubenschmid, Anoop Murthy Kavirayani, Maria Novatchkova, Michael Orthofer, Tsung‐Pin Pai, Domagoj Cikes, Sergei Zhuk, Meritxell Balmaña, Christopher Esk, Rubina Koglgruber, Paul Möseneder, Jelena Lazović, Lydia M. Zopf, , Josef Martin Penninger
This study identifies the HUSH complex as an epigenetic regulator of protocadherin expression in neurons, affecting brain development and neuronal diversity in mice and humans.
Science Advances · Nov 4, 2022Peer-reviewedNeuroscience