Leonhard X. Heinz

This study identifies IRF4 as a master regulator of multinucleated giant cell formation through integrated single-cell and bulk RNA sequencing, CRISPR/Cas9 editing, and in vivo fate mapping.

This study identifies NNMT as a key driver of fibroblast activation and skin fibrosis in systemic sclerosis by modulating TGFβ signaling and ECM production.

The paper performs a genome-wide CRISPR/Cas9 knock-out screen to identify genes involved in phagocytosis, validates key complexes, and maps their functional roles in human cells.

This study identifies PCYT2 as critical for muscle health and aging, showing its deficiency causes muscle weakness and aging, and demonstrates therapeutic potential through AAV-based delivery.