Author

Michael R. Das

Whitehead Institute for Biomedical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:multiome· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Ankur JainiD· 2 shared Yeonji ChangiD· 2 shared Cameron O. SchmitziD· 1 shared Colson TomberliniD· 1 shared Kelsey L. FarenhemiD· 1 shared Nan ZhangiD· 1 shared Rachel AndersoniD· 1 shared Reuben A. SaundersiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Ankur JainORCID

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2 papers

Recent·Most cited

CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs

Rachel Anderson, Michael R. Das, Yeonji Chang, Kelsey L. Farenhem, Cameron O. Schmitz, Ankur Jain

This study identifies that CAG repeat expansions create new splice acceptor sites, leading to aberrant repeat-containing RNAs that are translated via canonical AUG-initiated mechanisms.

Molecular Cell · Jan 30, 2024Peer-reviewedMolecular Biology

Flanking sequences regulate the toxicity, non-ATG translation, and aggregation of RNA with tandem CAG Repeats

Michael R. Das, Yeonji Chang, Reuben A. Saunders, Nan Zhang, Colson Tomberlin, Ronald D. Vale, Ankur Jain

The paper shows that flanking sequences of CAG repeat-containing RNA affect its toxicity, non-ATG translation, and cytoplasmic aggregation, linking these to neurodegenerative disease mechanisms.

bioRxiv · Aug 30, 2021 · PreprintMolecular Biology