Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis
Nathan Peroutka‐Bigus, Michael S. Sherman, Firat Kaya, Samanthi L. Waidyarachchi, Jiuyu Liu, Joel N. Rushefsky, Michelle M. Butler, Terry L. Bowlin, Bernd Meibohm, Mercedes Gonzalez Juarrero, Anne J. M. Lenaerts, Matthew Zimmerman, Richard E. Lee Jr., Gregory T. Robertson
This study evaluates replacing linezolid with spectinamide MBX-4888A in the Nix-TB regimen for tuberculosis in a mouse model, showing potential for reduced adverse effects.
Antimicrobial Agents and Chemotherapy · Sep 30, 2025Peer-reviewedMicrobiology