The Structural Basis of Pacs1-Wdr37 Complex Assembly and Stability
Le Xiao, Magdalena G. Grzemska, Xiong Pi, Luming Chen, Michael Turner, Nagesh Peddada, Samantha Calvache, Jessica Jia, Bruce Beutler, Hao Wu, Evan Nair‐Gill
This paper presents the cryo-EM structure of the Pacs1-Wdr37 complex, revealing its assembly mechanism and stability, and identifies a mutation linked to neurodevelopmental syndrome.
bioRxiv · Nov 5, 2025 · PreprintBiochemistry