Author

Magdalena G. Grzemska

The University of Texas Southwestern Medical CenterORCID 0000-0002-5306-3553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bruce BeutleriD· 2 shared Evan Nair‐GilliD· 2 shared Luming CheniD· 2 shared Nagesh PeddadaiD· 2 shared Samantha Calvache· 2 shared Ankita Bachhawat JaykumariD· 1 shared Aysha B. KhalidiD· 1 shared Clinton A. TayloriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

Bruce BeutlerORCID

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3 papers

Recent·Most cited

PPa1 insufficiency drives lysosomal storage disease and inflammatory macrophage expansion in the bone marrow.

Magdalena G. Grzemska, Luming Chen, Jamie L. Russell, Nagesh Peddada, Samantha Calvache, Jianhui Wang, Aysha B. Khalid, Jonathan J. Rios, Jeffrey A. SoRelle, Bruce Beutler, Evan Nair‐Gill

bioRxiv · Mar 18, 2026 · PreprintImmunology

The Structural Basis of Pacs1-Wdr37 Complex Assembly and Stability

Le Xiao, Magdalena G. Grzemska, Xiong Pi, Luming Chen, Michael Turner, Nagesh Peddada, Samantha Calvache, Jessica Jia, Bruce Beutler, Hao Wu, Evan Nair‐Gill

This paper presents the cryo-EM structure of the Pacs1-Wdr37 complex, revealing its assembly mechanism and stability, and identifies a mutation linked to neurodevelopmental syndrome.

bioRxiv · Nov 5, 2025 · PreprintBiochemistry

Predictive and Experimental Motif Interaction Analysis Identifies Functions of the WNK-OSR1/SPAK Pathway

Clinton A. Taylor, Ji-Ung Jung, Sachith Gallolu Kankanamalage, Justin Li, Magdalena G. Grzemska, Ankita Bachhawat Jaykumar, Svetlana A. Earnest, Steve Stippec, Purbita Saha, Eustolia Sauceda, Melanie H. Cobb

The paper identifies interaction motifs of the WNK-OSR1/SPAK pathway and validates their function through experimental testing.

Communications Biology · Sep 5, 2025Peer-reviewedBiochemistry