ANKLE2, a target of Zika virus, controls asymmetric cell division of neuroblasts and uncovers a novel microcephaly pathway
Nichole Link, Hyung-Lok Chung, Angad Jolly, Michael Withers, Burak Tepe, Benjamin Russell Arenkiel, P.S. Shah, Nevan J. Krogan, H. Aydın, Bilgen Bilge Geçkinli, Tülay Tos, Sedat Işıkay, Beyhan Tüysüz, Ganeshwaran H. Mochida, Ajay X. Thomas, , Hugo Jozef Bellen
This study identifies ANKLE2 as a Zika virus target that regulates neuroblast asymmetric division, linking it to microcephaly and motor neuron disease through interactions with VRK1 and LLGL1.
bioRxiv · Apr 17, 2019 · PreprintGenetics