Burak Tepe

This study compares 11 AAV serotypes for transduction efficiency and specificity in murine olfactory sensory neurons using nasal inoculation.

The paper identifies ceramide accumulation, lysosomal expansion, and mitochondrial defects as root causes of INAD/PARK14 and tests therapeutic strategies including drugs and gene therapy.

The paper develops new CRISPR-based constructs for Drosophila gene tagging, enabling efficient gene modification with a 70-80% success rate regardless of exon-intron structure.

This study identifies ANKLE2 as a Zika virus target that regulates neuroblast asymmetric division, linking it to microcephaly and motor neuron disease through interactions with VRK1 and LLGL1.