Author

Michael Xiong

Massachusetts Institute of TechnologyPrimary ORCID profile (0009-0003-6367-802X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Michael XiongiD1 paper · Massachusetts Institute of Technology

Biology Disciplines

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Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Matthew D. ShouldersiD· 2 shared Agata A. BikovtsevaiD· 1 shared Anton M. Barybin· 1 shared John F. BatemaniD· 1 shared Kathryn M. YammineiD· 1 shared Louis J. Papa· 1 shared Qi XieiD· 1 shared Richard P. SchiavoniiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSynthetic Biology

Matthew D. ShouldersORCID

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2 papers

Recent·Most cited

Synthesis of Ultra-Large Fibrous Proteins from Bacteria via a Looped-Translation System

Qi Xie, Louis J. Papa, Anton M. Barybin, Michael Xiong, Matthew D. Shoulders, Stephen D. Fried

This paper develops a looped-translation system in bacteria to synthesize ultra-large fibrous proteins, achieving molecular weights exceeding titin and enabling secretion.

bioRxiv · Jul 17, 2026 · PreprintSynthetic Biology

Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis

Kathryn M. Yammine, Sophia Mirda Abularach, Michael Xiong, Seo-yeon Kim, Agata A. Bikovtseva, Vincent L. Butty, Richard P. Schiavoni, John F. Bateman, Shireen R. Lamandé, Matthew D. Shoulders

The paper develops an iPSC-derived cartilage model to study COL2A1 mutations, revealing that Arg719Cys substitution causes defective collagen-II folding and secretion, leading to matrix dysfunction and osteoarthritis.

Life Science Alliance · Jul 9, 2024Peer-reviewedGenetics